methotrexate mtx Search Results


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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
Methotrexate Mtx, supplied by APP Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
Methotrexate (Mtx, supplied by LC Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
Methotrexate (Mtx), supplied by Ark Pharm Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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Tonghua Maoxiang Pharmaceutical Co Ltd methotrexate (mtx
<t>Methotrexate</t> (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.
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Image Search Results


Methotrexate (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.

Journal: G3: Genes|Genomes|Genetics

Article Title: Genomics of CpG Methylation in Developing and Developed Zebrafish

doi: 10.1534/g3.113.009514

Figure Lengend Snippet: Methotrexate (MTX) treatment of 3dpf zebrafish reduces genome-wide methylation in specific regions. (A) Methylation peak locations were compared between the untreated and MTX-treated 3dpf zebrafish samples. (B) Methylation ratio of 1000 bp of an intron and 100 bp of the adjacent exon, averaged for the entire genome. Untreated 3dpf in blue, MTX-treated 3dpf in red. (C) Enrichment of methylation peaks for peaks unique to the untreated 3dpf (blue), unique to MTX-treated 3dpf (red), and shared (purple) among common genomic elements. CpG refers to CpG islands. Error bars show SD.

Article Snippet: We applied 400 μM methotrexate (MTX; NDC 63323-123-10 102310; APP Pharmaceuticals) to one-cell zebrafish in E3 embryo medium.

Techniques: Genome Wide, Methylation